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Typical Drug Doses

Typical Chemotherapy Doses
Name Brand Name Common Dose (m2 = meters squared)
Actinomycin D Dactinomycin


0.5-1.0 mg/m2 IV infusion
Carboplatin Paraplatin 250-300 mg/m2 IV bolus (dogs)

10 mg/kg or 200-250 mg/m2 (cats)

Chlorambucil Leukeran Variable

2-6 mg/m2 PO daily

Cisplatin Platinol 30-70 mg/m2 IV drip with diuresis;
Cyclophosphamide Cytoxan 200-250 mg/m2 IV or PO 

50 mg/m2 PO 4 consecutive days/week;

Metronomic 12-15 mg/m2 PO daily

Cytosine arabinoside Cytosar Variable

300-600 mg/m2 IV infusion
50-300 mg/m2 SQ

Doxorubicin Adriamycin 25-30 mg/m2 IV infusion
1 mg/kg IV infusion for small dogs and cats (<15kg) Cardiotoxic, do not exceed180 m/m2 cumulative dose
Lomustine CCNU, CeeNU Variable

40-80 mg/m2 (dog)

10 mg per dose (cat)


L-Asparaginase Elspar 400 u/kg IM or SQ, max dose 10,000 u
Melphalen Alkeran Variable

1.5-2 mg/m2 PO

Mitoxantrone Novantrone 5-6 mg/m2 IV infusion (dog);
5.5-6.5 mg/m2 IV infusion (cat)
Piroxicam Feldene 0.3 mg/kg PO daily
Prednisone “Pred” Variable 

0.5-2 mg/kg PO daily

Procarbazine Matulane 50 mg/m2 PO
Rabacfosadine Tanovea-CA1 0.85-1 mg/m2 IV infusion
Toceranib Palladia 2.5-2.75 mg/kg PO 3-4x/week
Vinblastine Velban 1.5-3 mg/m2 IV bolus
Vincristine Oncovin 0.50.75 mg/m2 IV bolus
Anaphlaxis/Allergic Reaction
Diphenhydramine 2.2 mg/kg (1 mg/#)
Dex SP 0.1-0.2 mg/kg IV or IM
Vincristine/Vinblastine: STOP
  • Draw Back
  • Warm compress – 1 hour four times a day for 3-5 days
  • Hyaluronidase – 15-1500 units in 6 ml 0.9% NaCl, 6 clockwise injections around site using 25g needle, changing needle each time
Doxorubicin: STOP
  • Cold compress
  • Topical DMSO
  • Dexrazoxane 10 x the dose of dox IV. Administer within 3 hours, repeat at 24 and 48 hours